Author(s) Details:
Hou Yongmei
Department of Psychology, School of Humanities and Management, Guangdong Medical University, Dongguan, Guangdong Province, 523808, China.
This section is a part of the chapter: Pathogenic Factors of Tic Disorders in Children: Biological, Psychological and Social Factors
Magnetic resonance imaging found that during tic seizures, neural activity in the brain’s motor pathways increases, while the number of cholinergic interneurons in the striatum of tic patients decreases by more than 50% compared to normal controls, which also reduces the control of thalamic neurons on striatal neurons. At the same time, the core component of the Planar Cell Polarity (PCP) complex, CELSR3, can also inhibit striatal neurons by affecting cholinergic interneurons, which is believed to be related to the onset of tics (Kataoka et al., 2010; Wu et al., 2022). In addition, the abnormality of neurotransmitters causes abnormal information transmission in the nervous system and leads to the occurrence of tic disorders. Other studies have found that the levels of dopamine, norepinephrine, glutamate, and γ-aminobutyric acid in the plasma and urine of patients with tic disorders are higher than those of healthy children (Kanaan et al., 2017; Qian et al., 2022; Hao et al., 2022).
How to Cite
Nasrat, A. M., Nasrat, S. A., Nasrat, R. M., Nasrat, M. M., & Babiker, S. Y. (2025). Helicobacter pylori and Hyperuricemia: Revisiting Gout Diagnosis in Young Adults with Normal Renal Function. Medical Science: Trends and Innovations Vol. 4, 1–8. https://doi.org/10.9734/bpi/msti/v4/3641