Synergistic effects of HDAC and BET inhibitors have been observed in different cancer types, including neuroblastoma and glioblastoma. However, concurrent targeting of BET proteins and HDACs in MB remains unexplored. In this study, we tested the effects of BET inhibitor and HDAC inhibitor co-treatment on global gene expression, including SYK and MSI1 oncogenes; MYC protein expression; and anticancer efficacy against MYC-driven MB in vitro and in vivo.
Author(s) Details:
Matthew J. Kling,
Department of Oral Biology, Creighton University, School of Dentistry, Omaha, NE 68102, USA and Child Health Research Institute, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Varun Kesherwani,
Child Health Research Institute, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Nitish K. Mishra,
Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Gracey Alexander,
Department of Pediatrics, Hematology/Oncology Division, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Erin M. McIntyre,
Department of Pediatrics, Hematology/Oncology Division, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Sutapa Ray,
Child Health Research Institute, University of Nebraska Medical Center, Omaha, NE 68198, USA and Department of Pediatrics, Hematology/Oncology Division, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Kishore B. Challagundla,
Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Shantaram S. Joshi,
Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Don W. Coulter,
Child Health Research Institute, University of Nebraska Medical Center, Omaha, NE 68198, USA and Department of Pediatrics, Hematology/Oncology Division, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Nagendra K. Chaturvedi,
Child Health Research Institute, University of Nebraska Medical Center, Omaha, NE 68198, USA and Department of Pediatrics, Hematology/Oncology Division, University of Nebraska Medical Center, Omaha, NE 68198, USA and Department of Pediatrics, Hematology and Oncology Division, University of Nebraska Medical Center, Nebraska Medical Center, Omaha, NE 68198, USA.
